Gly-Gly-Gly-PEG4-methyltetrazine
Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Gly-Gly-Gly-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Product Specifications
CAS Number
[2353409-82-0]
UNSPSC
12352203
Hazard Statement
H315, H319, H335
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
97.89
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC1=NN=C(N=N1)C2=CC=C(C=C2)OCCOCCOCCOCCNC(CNC(CNC(CN)=O)=O)=O
Molecular Formula
C23H34N8O7
Molecular Weight
534.57
Precautions
H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Available Sizes
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