R121919 (Standard)
R121919 (Standard) is the analytical standard of R121919. This product is intended for research and analytical applications. R121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats[1][2][3].
Product Specifications
CAS Number
195055-03-9
UNSPSC
12352100
Target
CRFR; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Neurological Disease; Endocrinology
Smiles
CCCN(C1=CC(C)=NC2=C(C3=CN=C(N(C)C)C=C3C)C(C)=NN21)CCC
Molecular Formula
C22H32N6
Molecular Weight
380.53
References & Citations
[1]Gutman DA, et al. The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. J Pharmacol Exp Ther. 2003 Feb;304 (2) :874-80.|[2]Post A, et al. Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919) . Psychopharmacology (Berl) . 2005 Jun;180 (1) :150-8.|[3]Gutman DA, et al. Behavioral effects of the CRF1 recepator antagonist R121919 in rats selectively bred for high and low activity in the swim test. Psychoneuroendocrinology. 2008 Sep;33 (8) :1093-101.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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