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Methyltetrazine-PEG4-maleimide

Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-PEG4-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Product Specifications

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

PROTAC Linkers

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.61

Solubility

10 mM in DMSO

Smiles

O=C(NCCOCCOCCOCCOC1=CC=C(C2=NN=C(C)N=N2)C=C1)CCN3C(C=CC3=O)=O

Molecular Formula

C24H30N6O7

Molecular Weight

514.53

Precautions

H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-141278/Methyltetrazine-PEG4-maleimide-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

CAS Number

[1802908-02-6]

Available Sizes

Curated Selection

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