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4- (6-Methyl-1,2,4,5-tetrazin-3-yl) phenol

4- (6-Methyl-1,2,4,5-tetrazin-3-yl) phenol is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 4- (6-Methyl-1,2,4,5-tetrazin-3-yl) phenol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Product Specifications

CAS Number

58884-35-8

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

PROTAC Linkers

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.10

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C2=NN=C(C)N=N2)C=C1

Molecular Formula

C9H8N4O

Molecular Weight

188.19

Precautions

H302, H312, H332

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Alkyl-Chain Linkers

Available Sizes

Frequently Asked Questions

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