4- (6-Methyl-1,2,4,5-tetrazin-3-yl) phenol
4- (6-Methyl-1,2,4,5-tetrazin-3-yl) phenol is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 4- (6-Methyl-1,2,4,5-tetrazin-3-yl) phenol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Product Specifications
CAS Number
[58884-35-8]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
PROTAC Linkers
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.10
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=NN=C(C)N=N2)C=C1
Molecular Formula
C9H8N4O
Molecular Weight
188.19
Precautions
H302, H312, H332
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl-Chain Linkers
Available Sizes
Curated Selection
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