MK-5757

MK-5757 is a Nociceptin/Orphanin FQ Peptide Receptor antagonist. ORL1 antagonist 3 can improve cerebral blood flow disorders and ischemic damage, and alleviate abnormal neurological symptoms. ORL1 antagonist 3can be used for the research of neurological disease, such as traumatic brain injury[1].

Product Specifications

CAS Number

[919482-44-3]

UNSPSC

12352005

Target

Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

[H][C@]1(CC2)C[C@]2([H])C3(CC3)[C@H]1CN4CCC(N5C6=CC=CC=C6N(C5=O)C[C@@H](O)CO)CC4

Molecular Formula

C25H35N3O3

Molecular Weight

425.56

References & Citations

[1]Identification of an Orally Active Opioid Receptor-like 1 (ORL1) Receptor Antagonist 4-{3-[ (2R) -2,3-Dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[ (1S,3S,4R) -spiro[bicyclo[2.2.1]heptane-2,1′-cyclopropan]-3-ylmethyl]piperidine as Clinical Candidate J. Med. Chem., 2009, 52 (14), pp 4091-4094|[2]Kelly M. Standifer, et al. Methods of treating traumatic brain injury and related neurological conditions. US20240252585 A1. 2024-08-01