2-Acetyl-4-tetrahydroxybutyl imidazole

2-Acetyl-5-tetrahydroxybutyl imidazole is a potent sphingosine-1-phosphate (S1P) lyase inhibitor in vivo.

Product Specifications

CAS Number

[94944-70-4]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

LPL Receptor

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

98.06

Solubility

DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC[C@@H](O)[C@@H](O)[C@@H](C1=CN=C(C(C)=O)N1)O

Molecular Formula

C9H14N2O5

Molecular Weight

230.22

Precautions

H302, H312, H332

References & Citations

[1]Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders . Med. Chem., 2009, 52 (13), pp 3941-3953|[2]Schwab SR, et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science. 2005 Sep 9;309 (5741) :1735-9.