GSK189254A (Standard)
GSK189254A (Standard) is the analytical standard of GSK189254A. This product is intended for research and analytical applications. GSK189254A (GSK189254 free base) is a novel, potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.
Product Specifications
CAS Number
720690-73-3
UNSPSC
12352100
Target
Histamine Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Field of Research
Neurological Disease; Endocrinology
Smiles
O=C(NC)C(C=N1)=CC=C1OC2=CC(CC3)=C(C=C2)CCN3C4CCC4
Molecular Formula
C21H25N3O2
Molecular Weight
351.44
References & Citations
[1]Medhurst AD, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 2007 Jun;321 (3) :1032-45.|[2]Guo RX, et al. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.Br J Pharmacol. 2009 May;157 (1) :104-17.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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