DSPE-PEG2000-Maleimide (free acid)

DSPE-PEG2000-Maleimide free acid is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide free acid utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide free acid covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide free acid can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration[1][2][3][4].

Product Specifications

CAS Number

[185844-12-6]

UNSPSC

12352211

Target

Liposome

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Smiles

O=C1C=CC(N1CCC(NCCOCCOC(NCCOP(OC[C@@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O)=O.[n]

Molecular Weight

2000 (average)

References & Citations

[1]Nallamothu R, et al. A targeted liposome delivery system for combretastatin A4: formulation optimization through drug loading and in vitro release studies. PDA J Pharm Sci Technol. 2006;60 (3) :144-155. |[2]Gao J, et al. The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes. Biomaterials. 2011;32 (13) :3459-3470. |[3]Ishida T, et al. A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs. FEBS Lett. 1999 Oct 22;460 (1) :129-33. |[4]Herrera-Barrera M, et al. Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates. Sci Adv. 2023 Jan 13;9 (2) :eadd4623.