S7958
S7958 is a selective and orally active antagonist of the TAS2R8 bitter taste receptor, with its IC50 being 0.06 μM. S7958 only has a weak inhibitory effect on TASR8 and TAS2R39, and has no significant impact on other receptors. S7958 significantly inhibits the perception of bitterness caused by substances such as coffee and drug active ingredients (API) by selectively antagonizing the human bitter taste receptor TAS2R8. S7958 can be used in the medical field to improve the research on the bitterness of oral preparations[1].
Product Specifications
CAS Number
[1217341-48-4]
UNSPSC
12352005
Target
Taste Receptor
Related Pathways
GPCR/G Protein
Field of Research
Others
Smiles
O=C1N(C(C(C)(C)N1CC2=CC(O)=CC=C2)=O)C3=CN(CC4=C(C)ON=C4C)N=C3
Molecular Formula
C21H23N5O4
Molecular Weight
409.44
References & Citations
[1]Fotsing JR, et al. Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists. J Med Chem. 2020 May 14;63 (9) :4957-4977.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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