Pafolacianine (tetrasodium)

Pafolacianine tetrasodium (OTL 38 tetrasodium) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine tetrasodium excites at 774 to 775 nm and emits at 794 to 796 nm[1][2][3].

Product Specifications

CAS Number

[1628858-03-6]

Product Name Alternative

OTL 38 (tetrasodium)

UNSPSC

12352005

Target

Fluorescent Dye

Related Pathways

Others

Field of Research

Cancer

Smiles

O=S(CCCCN1C2=CC=C(S(=O)(O[Na])=O)C=C2C(C)(/C1=C/C=C3C(OC4=CC=C(C=C4)C[C@@H](C(O[Na])=O)NC(C5=CC=C(C=C5)NCC(N=C67)=CNC6=NC(N)=NC7=O)=O)=C(CCC\3)/C=C\C8=[N+](C9=CC=C(S(=O)([O-])=O)C=C9C8(C)C)CCCCS(=O)(O[Na])=O)C)(O[Na])=O

Molecular Formula

C61H63N9Na4O17S4

Molecular Weight

1414.42

References & Citations

[1]Jane J Keating, et, al. Intraoperative near-infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large-animal model. Cancer. 2017 May 15;123 (6) :1051-1060.|[2]Gul Z, et al. Pafolacianine, the magic wand of intraoperative imaging of folate-receptor positive ovarian cancer. Ann Transl Med. 2023 Oct 25;11 (11) :394.|[3]Ishiwata T, et al. Transbronchial real-time lung tumor localization with folate receptor-targeted near-infrared molecular imaging: A proof of concept study in animal models. J Thorac Cardiovasc Surg. 2023 Jun;165 (6) :e240-e251.