Zastaprazan (citrate)

Zastaprazan (JP-1366) citrate is a proton pump inhibitor and a potent potassium-competitive acid blocker. Zastaprazan citrate can be used in the research of gastrointestinal inflammatory diseases or gastric acid-related diseases such as gastroesophageal reflux disease[1][2].

Product Specifications

CAS Number

[2936619-43-9]

Product Name Alternative

JP-1366 (citrate)

UNSPSC

12352005

Target

Proton Pump

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Inflammation/Immunology

Smiles

O=C(CC(C(O)=O)(CC(O)=O)O)O.O=C(N1CCC1)C2=CN3C(C)=C(C)N=C3C(NCC4=C(C)C=CC=C4C)=C2.[x]

Molecular Formula

C22H26N4O.xC6H8O7

Molecular Weight

362.47 (free base)

References & Citations

[1]Oh JH, et al. Randomized, Double-Blind, Active-Controlled Phase 3 Study to Evaluate Efficacy and Safety of Zastaprazan Compared With Esomeprazole in Erosive Esophagitis. Am J Gastroenterol. 2025 Feb 1;120 (2) :353-361.|[2]Jeongmin Kim, et al. Imidazo[1,2-a]pyridine derivatives, methods for preparing the same and use thereof. WO2018008929A1. 2018-01-11.