GW0742 (Standard)
GW0742 (Standard) is the analytical standard of GW0742. This product is intended for research and analytical applications. GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively.
Product Specifications
CAS Number
317318-84-6
UNSPSC
12352100
Target
PPAR; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease; Cancer
Smiles
O=C(O)COC1=CC=C(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C(F)=C3)S2)C=C1C
Molecular Formula
C21H17F4NO3S2
Molecular Weight
471.49
References & Citations
[1]Sznaidman ML, et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta) --synthesis and biological activity. Bioorg Med Chem Lett. 2003 May 5;13 (9) :1517-21.|[2]Smith SA, et al. Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons. J Neurosci Res. 2004 Jul 15;77 (2) :240-9.|[3]Galuppo M, et al. GW0742, a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice. Int J Immunopathol Pharmacol. 2010 Oct-Dec;23 (4) :1033-46.|[4]Kuo SC, et al. Activation of receptors δ (PPARδ) by agonist (GW0742) may enhance lipid metabolism in heart both in vivo and in vitro. Horm Metab Res. 2013 Nov;45 (12) :880-6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400745-100 1x 100 µL
CD45 / LCA (2B11 + PD7/26), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC471409-500 1x 500 µL
MART-1 / Melan-A / MLANA (Melanoma Marker) (MLANA/1409R), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC042462-100 1x 100 µL
Ki-67 (Proliferating Cell Marker) (MKI67/2462), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details