GMQ

GMQ is an acid-sensing ion channel modulator, competitive GABAAR antagonist. GMQ preferentially, potently, competitively inhibits GABAARs. GMQ inhibits α1β2, α1β2γ2, α4β2γ2 and α5β2γ2 GABAARs. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion[1].

Product Specifications

CAS Number

[716-11-0]

Product Name Alternative

2-Guanidine-4-methylquinazoline

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

GABA Receptor

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

NC(NC1=NC(C)=C2C=CC=CC2=N1)=N

Molecular Formula

C10H11N5

Molecular Weight

201.23

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Xiao X, et al. 2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type γ-aminobutyric acid receptors. Neuropharmacology. 2013 Dec;75:126-37.