CCR5 antagonist 4
CCR5 antagonist 4 is an orally active CCR5 antagonist. CCR5 antagonist 4 can be studied in research on rheumatoid arthritis[1][2][3].
Product Specifications
CAS Number
[872879-86-2]
UNSPSC
12352005
Target
CCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(N(C1CCN(CC[C@@H](C2=CC(F)=CC(F)=C2)C3CCN(S(=O)(C)=O)CC3)CC1)CC)CC4=CC=C(S(=O)(C)=O)C=C4
Molecular Formula
C31H43F2N3O5S2
Molecular Weight
639.82
References & Citations
[1]Cumming, J. G., et al., (2012) . Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis. Bioorganic & medicinal chemistry letters, 22 (4), 1655-1659. |[2]Elsby, R., et al., (2011) . The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672. Drug metabolism and disposition: the biological fate of chemicals, 39 (2), 275-282.|[3]Gerlag, D. M., et al., (2010) . Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate. Arthritis and rheumatism, 62 (11), 3154-3160.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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