KVA-D-88
KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 and 880 nM for PDE4B and PDE4D, respectively. KVA-D-88 has the ability to inhibit cocaine-induced hyperlocomotor activity and sensitization. KVA-D-88 selectively inhibits PDE4B and reduces cAMP degradation, thereby modulating neuroadaptive responses. KVA-D-88 can be used in the study of cocaine addiction[1].
Product Specifications
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.81
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=CC=CN=C2N1C3=CC=C(Cl)C(Cl)=C3)N4CC(F)(F)C4
Molecular Formula
C17H11Cl2F2N3O
Molecular Weight
382.19
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139178/KVA-D-88-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
CAS Number
[2410550-31-9]
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) CNX2 Polyclonal Antibody
Recombinant Propionibacterium acnes Cell division protein SepF (sepF)
Recombinant Propionibacterium acnes Cell division protein SepF (sepF)
Recombinant Propionibacterium acnes Cell division protein SepF (sepF)
Recombinant Propionibacterium acnes Cell division protein SepF (sepF)