NS-398 (Standard)

NS-398 (Standard) is the analytical standard of NS-398. This product is intended for research and analytical applications. NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.

Product Specifications

CAS Number

[123653-11-2]

UNSPSC

12352100

Target

COX; Reference Standards

Related Pathways

Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology; Cancer

Smiles

CS(=O)(NC1=CC=C([N+]([O-])=O)C=C1OC2CCCCC2)=O

Molecular Formula

C13H18N2O5S

Molecular Weight

314.36

References & Citations

[1]Futaki N, et al. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994 Jan;47 (1) :55-9.|[2]Futaki N, et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol. 1993 Jan;24 (1) :105-10.