NS-398 (Standard)
NS-398 (Standard) is the analytical standard of NS-398. This product is intended for research and analytical applications. NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
Product Specifications
CAS Number
123653-11-2
UNSPSC
12352100
Target
COX; Reference Standards
Related Pathways
Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology; Cancer
Smiles
CS(=O)(NC1=CC=C([N+]([O-])=O)C=C1OC2CCCCC2)=O
Molecular Formula
C13H18N2O5S
Molecular Weight
314.36
References & Citations
[1]Futaki N, et al. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994 Jan;47 (1) :55-9.|[2]Futaki N, et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol. 1993 Jan;24 (1) :105-10.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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