N-Acetyl-S-geranylgeranyl-L-cysteine

N-Acetyl-S-geranylgeranyl-L-cysteine is a Methyltransferase inhibitor. N-Acetyl-S-geranylgeranyl-L-cysteine inhibits beta 2 integrin-induced actin polymerization with an IC50 of 45 nM[1].

Product Specifications

CAS Number

[139332-94-8]

Product Name Alternative

AGGC

UNSPSC

12352211

Hazard Statement

H225-H319

Target

DNA Methyltransferase; Integrin

Related Pathways

Cytoskeleton; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CSC[C@@H](C(O)=O)NC(C)=O

Molecular Formula

C25H41NO3S

Molecular Weight

435.66

Precautions

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501

References & Citations

[1]Molony L, et al. Inhibitors of farnesyl and geranylgeranyl methyltransferases prevent beta 2 integrin-induced actin polymerization without affecting beta 2 integrin-induced Ca2+ signaling in neutrophils. Biochem Biophys Res Commun. 1996 Jun 25;223 (3) :612-7.