III-31-C
III-31-C is a (hydroxyethyl) urea γ-secretase inhibitor. III-31-C inhibits Aऔ production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research[1].
Product Specifications
CAS Number
398515-96-3
UNSPSC
12352005
Target
γ-secretase
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(OC)=O)=O)N(C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1)CC2=CC=CC=C2
Molecular Formula
C35H52N4O7
Molecular Weight
640.81
References & Citations
[1]Kornilova AY, et al. Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem. 2003 May 9;278 (19) :16470-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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