III-31-C

III-31-C is a (hydroxyethyl) urea γ-secretase inhibitor. III-31-C inhibits Aऔ production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research[1].

Product Specifications

CAS Number

[398515-96-3]

UNSPSC

12352005

Target

γ-secretase

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(OC)=O)=O)N(C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1)CC2=CC=CC=C2

Molecular Formula

C35H52N4O7

Molecular Weight

640.81

References & Citations

[1]Kornilova AY, et al. Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem. 2003 May 9;278 (19) :16470-3.