GANT 61 (Standard)
GANT 61 (Standard) is the analytical standard of GANT 61. This product is intended for research and analytical applications. GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
Product Specifications
CAS Number
500579-04-4
UNSPSC
12352100
Target
Autophagy; Gli; Reference Standards
Related Pathways
Autophagy; Others; Stem Cell/Wnt
Field of Research
Cancer
Smiles
CN(C)C1=CC=CC=C1CN2C(C3=CC=NC=C3)N(CC4=CC=CC=C4N(C)C)CCC2
Molecular Formula
C27H35N5
Molecular Weight
429.60
References & Citations
[1]Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71 (3) :1092-102.|[2]Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330 (1) :22-32.|[3]Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132 (7) :1516-24.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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