GANT 61 (Standard)

GANT 61 (Standard) is the analytical standard of GANT 61. This product is intended for research and analytical applications. GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.

Product Specifications

CAS Number

[500579-04-4]

UNSPSC

12352100

Target

Autophagy; Gli; Reference Standards

Related Pathways

Autophagy; Others; Stem Cell/Wnt

Field of Research

Cancer

Smiles

CN(C)C1=CC=CC=C1CN2C(C3=CC=NC=C3)N(CC4=CC=CC=C4N(C)C)CCC2

Molecular Formula

C27H35N5

Molecular Weight

429.60

References & Citations

[1]Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71 (3) :1092-102.|[2]Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330 (1) :22-32.|[3]Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132 (7) :1516-24.