CYP4Z1-IN-2

CYP4Z1-IN-2 (compound 7) is a reversible inhibitor of CYP4Z1 (Ki=2.2 μM), which inhibits the production of 14,15-EET in breast cancer cells. CYP4Z1-IN-2 inhibits the CYP4Z1-mediated Luc-BE O-debenzylation reaction with an IC50 of 5.9 μM[1].

Product Specifications

CAS Number

[2428734-45-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Cytochrome P450

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(O)CCCCCCCNN1N=NC2=CC=CC=C21

Molecular Formula

C14H20N4O2

Molecular Weight

276.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kowalski JP, et al. Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1. J Med Chem. 2020 May 14;63 (9) :4824-4836.