BRF110
BRF110 is the selective, orally active rexinoid for Nurr1-RXRα, that selectively activates the Nurr1-RXRα heterodimer with an EC50 of 0.9 μM in SH-SY5Y. BRF110 upregulates the expression of BDNF, exhibits neuroprotective activity against MPP+ induced toxicity. BRF110 can cross blood-brain barrier[1].
Product Specifications
CAS Number
2095489-35-1
UNSPSC
12352005
Target
Nuclear Hormone Receptor 4A/NR4A; RAR/RXR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Neurological Disease
Smiles
O=C(O)C1=CC=C(N(C)C2=NC(C3=CC=CC=C3)=NC(C(F)(F)F)=C2CC=C)C=C1
Molecular Formula
C22H18F3N3O2
Molecular Weight
413.39
References & Citations
[1]Asvos X, et al., BRF110, an Orally Active Nurr1-RXRα-Selective Rexinoid, Enhances BDNF Expression without Elevating Triglycerides. J Med Chem. 2025 Feb 27;68 (4) :4763-4786.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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