TC-PTP-IN-1

TC-PTP-IN-1 (compound 8) is a potent TC-PTP inhibitor with an IC50 value of 9.2 nM, Ki values of 4.3, 34 nM for TC-PTP, PTP1B, respectively. TC-PTP-IN-1 increases the protein expression of pSre416[1]. TC-PTP-IN-1 (compound 3) is the TC-PTP Ligand of TP1L (HY-160151) [2].

Product Specifications

CAS Number

[1187396-28-6]

UNSPSC

12352005

Target

Phosphatase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=P(O)(O)C(F)(F)C(C=C1)=CC=C1C[C@@H](C(N[C@H](C(N)=O)CCCCNC(C2=CC=C(C=C2)CC)=O)=O)NC([C@@H](NC(CO[C@@H]3[C@H](CC[C@@H](C3)C)C(C)C)=O)CC4=CC=CC=C4)=O

Molecular Formula

C46H62F2N5O9P

Molecular Weight

897.98

References & Citations

[1]Zhang S, et al. Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. J Am Chem Soc. 2009 Sep 16;131 (36) :13072-9.|[2]Miao J, et al. Discovery of a selective TC-PTP degrader for cancer immunotherapy. Chem Sci. 2023 Oct 24;14 (44) :12606-12614.