MAY0132
MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. MAY0132 significantly inhibits replication of HMPV, AdV and RSV, reduces viral infection-induced cytokine/chemokine production, and inhibits NF-κB activation. MAY0132 has antiviral activity and can be used in the study of respiratory virus infection[1][2].
Product Specifications
CAS Number
1895861-88-7
UNSPSC
12352005
Target
NF-κB; RSV
Related Pathways
Anti-infection; NF-κB
Field of Research
Infection
Smiles
CC1=C(NC2=CC=C(Cl)C(C(F)(F)F)=C2)C(C)=CC(C)=C1
Molecular Formula
C16H15ClF3N
Molecular Weight
313.75
References & Citations
[1]Choi EJ, et al. Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections. Viruses. 2021 Jun 21;13 (6) :1179.|[2]Wild CT, et al. Functionalized N, N-Diphenylamines as Potent and Selective EPAC2 Inhibitors. ACS Med Chem Lett. 2016 Mar 28;7 (5) :460-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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