Tetraacetylphytosphingosine

Tetraacetylphytosphingosine is a sphingolipid metabolite produced by phytosphingosine acetylation. Tetraacetylphytosphingosine exerts its inhibitory action on angiogenesis through the inhibition of MAPK activation and intracellular calcium increase[1]. Tetraacetylphytosphingosine induces apoptosis in HaCaT cells[2].

Product Specifications

CAS Number

[13018-48-9]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; p38 MAPK

Related Pathways

Apoptosis; MAPK/ERK Pathway

Field of Research

Cancer; Cardiovascular Disease

Purity

99.90

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](NC(C)=O)COC(C)=O

Molecular Formula

C26H47NO7

Molecular Weight

485.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Yoo Bin Kwon, et al. Anti-angiogenic effect of tetraacetyl-phytosphingosine. Exp Dermatol. 2007 Apr;16 (4) :311-7. |[2]H J Kim, et al. Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin. Apoptosis. 2004 Jul;9 (4) :449-56.