Enzyme-IN-3 (disodium)

Enzyme-IN-3 disodium (compound 7) is a selective inhibitor of Mycobacterium tuberculosis shikimate kinase with an IC50 of 1.6 μM. Enzyme-IN-3 disodium has antibacterial activity[1][2].

Product Specifications

CAS Number

[122855-18-9]

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=S(C1=C(/N=N/C2=CC=C3C(O)=CC(S(=O)(O[Na])=O)=CC3=C2)C(O)=C4C=CC(N)=CC4=C1)(O[Na])=O

Molecular Formula

C20H13N3Na2O8S2

Molecular Weight

533.44

References & Citations

[1]Gordon S, et al. Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials. Perspect Medicin Chem. 2015 Mar 15;7:9-20.|[2]Prado V, et al. Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme. J Med Chem. 2016 Jun 9;59 (11) :5471-87.