2- (2,6-Dioxopiperidin-3-yl) phthalimidine (Standard)

2- (2,6-Dioxopiperidin-3-yl) phthalimidine (Standard) is the analytical standard of 2- (2,6-Dioxopiperidin-3-yl) phthalimidine. This product is intended for research and analytical applications. 2- (2,6-Dioxopiperidin-3-yl) phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2- (2,6-Dioxopiperidin-3-yl) phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas[1][2].

Product Specifications

CAS Number

[26581-81-7]

UNSPSC

12352100

Target

Reference Standards; TNF Receptor

Related Pathways

Apoptosis; Others

Field of Research

Cancer

Smiles

O=C(C(N(CC1=C2C=CC=C1)C2=O)CC3)NC3=O

Molecular Formula

C13H12N2O3

Molecular Weight

244.25

References & Citations

[1]Merker HJ, et al. Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. I. Effects of 3- (1,3-dihydro-1-oxo-2H-isoindol-2-yl) -2,6-dioxopiperidine (EM12) on skeletal development. Arch Toxicol. 1988;61 (3) :165-179.|[2]Gershbein LL. The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas. Cancer Lett. 1991;60 (2) :129-133.