ST4070

ST4070 is a potent, orally active, and selective reversible fatty acid amide hydrolase (FAAH) inhibitor. ST4070 increases endocannabinoid (eCB) brain levels and counteracts neuropathic pain in animal models. ST4070 enhances the endogenous eCB tone in specific brain regions engaged in emotional control, and induces remarkable anxiolytic-like behaviours in rodents. ST4070 can be used for neuropathic pain and anxiety disorders research[1][2].

Product Specifications

CAS Number

[1186236-75-8]

UNSPSC

12352005

Target

FAAH

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(N1CCCCC1)OC(C2=CC=C(C3=CC=CC=C3)C=C2)=C

Molecular Formula

C20H21NO2

Molecular Weight

307.39

References & Citations

[1]Costanzo MJ, et al. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. Bioorg Med Chem Lett. 2008 Mar 15;18 (6) :2114-21.|[2]Marco EM, et al. Potential Therapeutic Value of a Novel FAAH Inhibitor for the Treatment of Anxiety. PLoS One. 2015 Sep 11;10 (9) :e0137034.