Janelia Fluor® 646, Tetrazine

Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging[1]. Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Product Specifications

CAS Number

[2042192-00-5]

Product Name Alternative

JF646, Tetrazine

UNSPSC

12171500

Target

Fluorescent Dye

Related Pathways

Others

Field of Research

Others

Purity

95.29

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C(C2=C([Si](C)(C)C3=C/4)C=C(N5CCC5)C=C2)=C3C=CC4=[N+]6CCC/6)C=C(C(NCC7=CC=C(C8=NN=CN=N8)C=C7)=O)C=C1)[O-]

Molecular Formula

C38H35N7O3Si

Molecular Weight

665.82

References & Citations

[1]Grimm JB, et al. A general method to improve fluorophores for live-cell and single-molecule microscopy. Nat Methods. 2015;12 (3) :244-250. doi:10.1038/nmeth.3256|[2]Basu S, et al. FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells. Nat Commun. 2018;9 (1) :2520. Published 2018 Jun 28.