AST5902 (trimesylate) (Standard)

AST5902 (trimesylate) (Standard) is the analytical standard of AST5902 (trimesylate) . This product is intended for research and analytical applications. AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor[1].

Product Specifications

CAS Number

[2929417-90-1]

UNSPSC

12352005

Target

Drug Metabolite; EGFR; Reference Standards

Related Pathways

JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CS(=O)(O)=O.C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(C)CCNC)=O.CS(=O)(O)=O.CS(=O)(O)=O

Molecular Formula

C30H41F3N8O11S3

Molecular Weight

842.88

References & Citations

[1]Xiao-yun Liu, et al. Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. Acta Pharmacol Sin. 2020 Oct; 41 (10) : 1366-1376.