AST5902 (trimesylate) (Standard)
AST5902 (trimesylate) (Standard) is the analytical standard of AST5902 (trimesylate) . This product is intended for research and analytical applications. AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor[1].
Product Specifications
CAS Number
2929417-90-1
UNSPSC
12352005
Target
Drug Metabolite; EGFR; Reference Standards
Related Pathways
JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CS(=O)(O)=O.C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(C)CCNC)=O.CS(=O)(O)=O.CS(=O)(O)=O
Molecular Formula
C30H41F3N8O11S3
Molecular Weight
842.88
References & Citations
[1]Xiao-yun Liu, et al. Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. Acta Pharmacol Sin. 2020 Oct; 41 (10) : 1366-1376.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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