PF-06862309
PF-06862309 is a PF-06843195 (HY-131972) phosphate ester prodrug. PF-06862309 can be hydrolyzed to PF-06843195 in the presence of alkaline phosphatase. PF-06843195 is a highly selective PI3Kα inhibitor. PF-06862309 can be used for the study of breast cancer with ER+, HER2-, and PIK3CA mutations[1].
Product Specifications
CAS Number
[2067281-52-9]
UNSPSC
12352005
Target
Drug Intermediate
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=[P](O)(O)OC[C@@](CN1C(OCC(F)F)=O)(CC1)NC2=NC(N3CCOCC3)=NC(C(C=N4)=CN=C4N)=C2F
Molecular Formula
C20H26F3N8O7P
Molecular Weight
578.44
References & Citations
[1]Hengmiao Cheng, et al. Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195) . J Med Chem. 2021 Jan 14;64 (1) :644-661.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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