Stattic (Standard)

Stattic (Standard) is the analytical standard of Stattic. This product is intended for research and analytical applications. Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727) [1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice[3].

Product Specifications

CAS Number

[19983-44-9]

UNSPSC

12352100

Target

Apoptosis; Reference Standards; STAT

Related Pathways

Apoptosis; JAK/STAT Signaling; Others; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=[N+](C1=CC=C(C=CS2(=O)=O)C2=C1)[O-]

Molecular Formula

C8H5NO4S

Molecular Weight

211.19

References & Citations

[1]Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12.|[2]John S McMurray, et al. A new small-molecule Stat3 inhibitor. Chem Biol. 2006 Nov;13 (11) :1123-4.|[3]Tsubasa Yokota, et al. STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model. Nephrol Dial Transplant. 2018 Feb 1;33 (2) :214-223.