QNZ (Standard)
QNZ (Standard) is the analytical standard of QNZ. This product is intended for research and analytical applications. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.
Product Specifications
CAS Number
545380-34-5
UNSPSC
12352100
Target
NF-κB; Reference Standards; TNF Receptor
Related Pathways
Apoptosis; NF-κB; Others
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
NC1=CC2=C(NCCC3=CC=C(OC4=CC=CC=C4)C=C3)N=CN=C2C=C1
Molecular Formula
C22H20N4O
Molecular Weight
356.42
References & Citations
[1]Tobe M, et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation.|[2]Nekrasov ED, et al. Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons. Mol Neurodegener. 2016 Apr 14;11:27.|[3]Wu J, et al. Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model. J Neurosci. 2016 Jan 6;36 (1) :125-41.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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