Desmethyl etoricoxib
Desmethyl etoricoxib (example 21) is a selective COX-2 inhibitor with an IC50 of 1 μM in whole blood. Desmethyl etoricoxib inhibits COX-1 with an IC50 of 16 μM in U937 cells. Desmethyl etoricoxib has anti-inflammatory effects[1].
Product Specifications
CAS Number
202409-31-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
COX
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=CN=C3)C=C1)(C)=O
Molecular Formula
C17H13ClN2O2S
Molecular Weight
344.82
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Daniel Dube, et al. Substituted pyridines as selective cyclooxygenase-2 inhibitors. WO9803484A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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