7-Acetyl paclitaxel

7-Acetyl paclitaxel is a microtubule depolymerization inhibitor which inhibits calcium-induced microtubule depolymerization. 7-Acetyl paclitaxel reduces the growth of J774.2 macrophages (IC50 ~ 60 nM) and increases the levels of nitric oxide (NO) and TNF in isolated mouse peritoneal macrophages[1].

Product Specifications

CAS Number

[92950-39-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Others

Purity

98.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(O[C@]([C@@]1([H])C[C@@H]2OC(C)=O)(CO1)[C@]([C@@H]([C@@](C3(C)C)(C[C@@H]4OC([C@H](O)[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)O)OC(C7=CC=CC=C7)=O)([H])[C@@]2(C([C@@H](C3=C4C)OC(C)=O)=O)C)=O

Molecular Formula

C49H53NO15

Molecular Weight

895.94

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Ojima I, et al. Structure-activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells. Bioorg Med Chem. 2003 Jul 3;11 (13) :2867-88.