7-Acetyl paclitaxel
7-Acetyl paclitaxel is a microtubule depolymerization inhibitor which inhibits calcium-induced microtubule depolymerization. 7-Acetyl paclitaxel reduces the growth of J774.2 macrophages (IC50 ~ 60 nM) and increases the levels of nitric oxide (NO) and TNF in isolated mouse peritoneal macrophages[1].
Product Specifications
CAS Number
92950-39-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Others
Purity
98.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(O[C@]([C@@]1([H])C[C@@H]2OC(C)=O)(CO1)[C@]([C@@H]([C@@](C3(C)C)(C[C@@H]4OC([C@H](O)[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)O)OC(C7=CC=CC=C7)=O)([H])[C@@]2(C([C@@H](C3=C4C)OC(C)=O)=O)C)=O
Molecular Formula
C49H53NO15
Molecular Weight
895.94
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Ojima I, et al. Structure-activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells. Bioorg Med Chem. 2003 Jul 3;11 (13) :2867-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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