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SC-514 (Standard)

SC-514 (Standard) is the analytical standard of SC-514. This product is intended for research and analytical applications. SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

Product Specifications

CAS Number

354812-17-2

UNSPSC

12352100

Target

IKK; Reference Standards

Related Pathways

NF-κB; Others

Field of Research

Cancer

Smiles

O=C(C1=C(N)C=C(C2=CSC=C2)S1)N

Molecular Formula

C9H8N2OS2

Molecular Weight

224.30

References & Citations

[1]Kishore N, et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem. 2003 Aug 29;278 (35) :32861-71.|[2]Tse AK, et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017 Apr;11:562-576.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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