SC-514 (Standard)
SC-514 (Standard) is the analytical standard of SC-514. This product is intended for research and analytical applications. SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
Product Specifications
CAS Number
[354812-17-2]
UNSPSC
12352100
Target
IKK; Reference Standards
Related Pathways
NF-κB; Others
Field of Research
Cancer
Smiles
O=C(C1=C(N)C=C(C2=CSC=C2)S1)N
Molecular Formula
C9H8N2OS2
Molecular Weight
224.30
References & Citations
[1]Kishore N, et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem. 2003 Aug 29;278 (35) :32861-71.|[2]Tse AK, et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017 Apr;11:562-576.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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