SP-8008

SP-8008 is a selective shear stress-induced platelet aggregation (SIPA) inhibitor with an IC50 of 1.44 μM. SP-8008 effectively interferes von Willebrand factor (vWF) and platelet glycoprotein (GP) Ib interaction. SP-8008 exerts its antithrombotic effect by selectively inhibiting shear stress-induced platelet aggregation[1].

Product Specifications

CAS Number

[2088247-61-2]

UNSPSC

12352005

Target

Integrin

Related Pathways

Cytoskeleton

Field of Research

Cardiovascular Disease

Smiles

O=C(OC1=C(CC)OC=CC1=O)C2=CC=C(O)C(OC)=C2

Molecular Formula

C15H14O6

Molecular Weight

290.27

References & Citations

[1]Ngo T, et al. Antithrombotic effect of SP-8008, a benzoic acid derivative, through the selective inhibition of shear stress-induced platelet aggregation. Br J Pharmacol. 2020 Feb;177 (4) :929-944.