Zelpolib
Zelpolib is a non-competitive Pol δ inhibitor. Zelpolib shows robust inhibition of Pol δ activity against dTTP with a Ki of 4.3 μM. Zelpolib inhibits cellular DNA replication. Zelpolib shows antiproliferative properties[1].
Product Specifications
CAS Number
701932-26-5
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(OC)C=1C=C(SC1NC(=S)NNC(=O)CCC2=CC=C(O)C(O)=C2)C=3C=CC=CC3
Molecular Formula
C22H21N3O5S2
Molecular Weight
471.55
References & Citations
[1]Mishra B, et al. Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties. Cancer Biol Ther. 2019;20 (4) :474-486.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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