TGF-βRI inhibitor 3
TGF-βRI inhibitor 3 (Compound 9ac) is a selective TGF-β inhibitor. TGF-βRI inhibitor 3 can effectively inhibit the TGF-β signaling pathway. TGF-βRI inhibitor 3 has IC50 values of 13 μM and 0.63 μM for c-Src kinase and ALK5 kinase, respectively[1].
Product Specifications
CAS Number
[666729-57-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Anaplastic lymphoma kinase (ALK) ; Src; TGF-β Receptor
Related Pathways
Protein Tyrosine Kinase/RTK; TGF-beta/Smad
Field of Research
Others
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=CC(C)=C(C)C=C1OC2=CC=NC3=CC(OC)=C(OC)C=C23)=O
Molecular Formula
C21H21NO4
Molecular Weight
351.40
Precautions
H302, H315, H319
References & Citations
[1]Shimizu T, et al. Synthesis and evaluation of [2- (4-quinolyloxy) phenyl]methanone derivatives: novel selective inhibitors of transforming growth factor-beta kinase. J Med Chem. 2008 Jun 12;51 (11) :3326-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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