O6BTG-C8-αGlu
O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, O6BTG-C8-αGlu can completely inhibit MGMT in HeLaS3 cells. Even when applied chronically at high doses (up to 20 μM), it does not exhibit cytotoxicity. O6BTG-C8-αGlu is suitable for research on MGMT-related cancer diseases[1].
Product Specifications
CAS Number
[793035-88-8]
UNSPSC
12352005
Target
DNA Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
BrC1=CSC(COC2=C3C(N(C=N3)CCCCCCCCO[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=NC(N)=N2)=C1
Molecular Formula
C24H34BrN5O7S
Molecular Weight
616.53
References & Citations
[1]Kaina B, et al. Inhibition of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors: comparison with nonconjugated inhibitors and effect on fotemustine and temozolomide-induced cell death. J Pharmacol Exp Ther. 2004 Nov;311 (2) :585-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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