Pemetrexed (disodium hemipenta hydrate) (Standard)

Pemetrexed (disodium hemipenta hydrate) (Standard) is the analytical standard of Pemetrexed (disodium hemipenta hydrate) . This product is intended for research and analytical applications. Pemetrexed disodium hemipenta hydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.

Product Specifications

CAS Number

[357166-30-4]

UNSPSC

12352100

Target

Antifolate; Apoptosis; Autophagy; Reference Standards

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Smiles

O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C1=CC=C(CCC2=CNC(N=C(N)N3)=C2C3=O)C=C1)=O.[2.5H2O]

Molecular Formula

C20H24N5Na2O8.5

Molecular Weight

516.41

References & Citations

[1]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57 (6) :1116-23.|[2]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185 (2) :956-66.