MANT-cGMP

MANT-cGMP, a ribose-substituted nucleotide, is an adenylyl cyclase (AC) inhibitor with a Ki of 100 μM and a pKi of 4. MANT-cGMP can be used for the study of heart failure, cancer, and neurological disorders[1].

Product Specifications

CAS Number

[83707-15-7]

UNSPSC

12352005

Target

Adenylate Cyclase

Related Pathways

GPCR/G Protein

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Smiles

O=C(C(C=CC=C1)=C1NC)O[C@H]2[C@@](N3C(NC(N)=NC4=O)=C4N=C3)([H])O[C@@](CO5)([H])[C@@]2([H])O[P]5(O)=O

Molecular Formula

C18H19N6O8P

Molecular Weight

478.35

References & Citations

[1]Wang JL, et al. A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors. Bioorg Med Chem. 2007 Apr 15;15 (8) :2993-3002.