MANT-dADP (trisodium)

MANT-dADP (trisodium) (2'-Deoxy-3'-MANT-ADP (trisodium) ) is a fluorescent nucleotide derivative, with an emission maximum of 453 nm upon excitation at 350 nm. MANT-dADP (trisodium) can decrease inositol phoshate formation in CHO-K1 cells that express human purinergic P2Y12 receptor. MANT-dADP (trisodium) can be studied in research on the interaction between cardiac troponin I and myofibrils[1][2][3].

Product Specifications

Product Name Alternative

2'-Deoxy-3'-MANT-ADP (trisodium)

UNSPSC

12352005

Target

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Smiles

NC(N=CN=C12)=C1N=CN2[C@@H]3O[C@H](COP(OP(O[Na])(O[Na])=O)(O[Na])=O)[C@@H](OC(C4=C(C=CC=C4)NC)=O)C3

Molecular Formula

C18H19N6Na3O10P2

Molecular Weight

610.29

References & Citations

[1]Bujalowski W, et al., Structural characteristics of the nucleotide-binding site of Escherichia coli primary replicative helicase DnaB protein. Studies with ribose and base-modified fluorescent nucleotide analogs. Biochemistry. 1994 Apr 19;33 (15) :4682-94. |[2]Schmidt P, et al., Identification of determinants required for agonistic and inverse agonistic ligand properties at the ADP receptor P2Y12. Mol Pharmacol. 2013 Jan;83 (1) :256-66. |[3]Gunther LK, et al., Effect of N-Terminal Extension of Cardiac Troponin I on the Ca (2+) Regulation of ATP Binding and ADP Dissociation of Myosin II in Native Cardiac Myofibrils. Biochemistry. 2016 Mar 29;55 (12) :1887-97.