Motolimod (Standard)

Motolimod (Standard) is the analytical standard of Motolimod. This product is intended for research and analytical applications. Motolimod (VTX-2337; VTX-378) is a selective Toll-like receptor 8 (TLR8) agonist, with an EC50 of approximately 100 nM.

Product Specifications

CAS Number

[926927-61-9]

UNSPSC

12352100

Target

Reference Standards; Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation; Others

Field of Research

Cancer

Smiles

O=C(C1=CC2=CC=C(C3=CC=C(C(N4CCCC4)=O)C=C3)C=C2N=C(N)C1)N(CCC)CCC

Molecular Formula

C28H34N4O2

Molecular Weight

458.60

References & Citations

[1]Lu H, et al. VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res. 2012 Jan 15;18 (2) :499-509.|[2]Dietsch GN, et al. Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity. PLoS One. 2016 Feb 29;11 (2) :e0148764.