COPCP (trisodium)
COPCP trisodium (Compound 7a) is a potent and selective ecto-5'-nucleotidase CD73 inhibitor. COPCP trisodium blocks CD73-mediated adenosine production, reducing the inhibitory effect of adenosine on immune cells. COPCP trisodium is promising for research of cancers[1].
Product Specifications
UNSPSC
12352005
Target
CD73
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O[C@@H]1[C@H](O)[C@@H](COP(CP(O[Na])(O[Na])=O)(O[Na])=O)O[C@H]1N2C=CC(N)=NC2=O
Molecular Formula
C10H14N3Na3O10P2
Molecular Weight
467.15
References & Citations
[1]Junker A, et al. Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2019 Apr 11;62 (7) :3677-3695.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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