2'2'-cGAMP
2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP binds weaker binding to STING than 2'3'-cGAMP but stronger than other CDNs[1].
Product Specifications
CAS Number
1465774-27-9
UNSPSC
12352005
Target
Endogenous Metabolite; IFNAR; STING
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O[C@H]1[C@](O[P](O)(OC[C@@]([C@H]2O)([H])O[C@](N3C4=NC=NC(N)=C4N=C3)([H])[C@]2([H])O5)=O)([H])[C@](O[C@]1([H])CO[P]5(O)=O)([H])N6C(NC(N)=NC7=O)=C7N=C6
Molecular Formula
C20H24N10O13P2
Molecular Weight
674.41
References & Citations
[1]Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013;51 (2) :226-235.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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