3'2'-cGAMP
3'2'-cGAMP (c[A (2',5') pG (3',5') p]) is a cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) isomer. 3'2'-cGAMP exhibits high selectivity for Drosophila STING (dSTING), activating the dSTING-NF-κB signaling pathway, inducing the expression of Sting-regulated genes (Srg) and conferring a potent antiviral state in vivo. 3'2'-cGAMP is resistant to cleavage by viral poxins. 3'2'-cGAMP can be used for the study of viral infections[1].
Product Specifications
CAS Number
[1615704-64-7]
Product Name Alternative
C[A (2',5') pG (3',5') p]
UNSPSC
12352005
Target
NF-κB; STING
Related Pathways
Immunology/Inflammation; NF-κB
Field of Research
Infection
Smiles
O=C1C(N=CN2[C@H]3[C@H](O)[C@H](OP4(O)=O)[C@@H](COP(O)(O[C@@H]5[C@H](O)[C@@H](CO4)O[C@H]5N(C=N6)C7=C6C(N)=NC=N7)=O)O3)=C2N=C(N)N1
Molecular Formula
C20H24N10O13P2
Molecular Weight
674.41
References & Citations
[1]Slavik KM, et al. cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila. Nature. 2021 Sep;597 (7874) :109-113.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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