Guanosine 5'-O- (2-thiodiphosphate) (trisodium)

Guanosine 5'-O- (2-thiodiphosphate) (trisodium) (GDPβS (trisodium) ) is a non-hydrolyzable derivative of GDP. Guanosine 5'-O- (2-thiodiphosphate) (trisodium) is an inhibitor of adenylyl caclase (AC) (Ki = 600 nM) . Guanosine 5'-O- (2-thiodiphosphate) (trisodium) partially activates AC in the absence of GPT in cerebral cortex membranes of rodent models (EC50 = 400 nM) . Guanosine 5'-O- (2-thiodiphosphate) (trisodium) prevents the release of norepinephrine-induced nitric oxide in cardiac ventricular myocytes[1][2][3].

Product Specifications

Product Name Alternative

GDPβS (trisodium)

UNSPSC

12352005

Target

Adenylate Cyclase

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Concentration

10 mM * 437.92 μL in Water

Purity

97.1

Smiles

NC1=NC(C2=C(N1)N(C=N2)[C@@H]3O[C@H](COP(OP(O[Na])(S[Na])=O)(O[Na])=O)[C@@H](O)[C@H]3O)=O

Molecular Formula

C10H12N5Na3O10P2S

Molecular Weight

525.21

References & Citations

[1]Svoboda, M., et al., (1980) . Guanosine 5'-O- (2-thiodiphosphate) as a competitive inhibitor of GTP in hormone or cholera toxin-stimulated pancreatic adenylate cyclase. FEBS letters, 109 (2), 275–279.|[2]Rasenick, M. M., et al., (1989) . Guanosine-5'-O-thiodiphosphate functions as a partial agonist for the receptor-independent stimulation of neural adenylate cyclase. Brain research, 488 (1-2), 105–113. |[3]Kanai, A. J., (1997) . Beta-adrenergic regulation of constitutive nitric oxide synthase in cardiac myocytes. The American journal of physiology, 273 (4), C1371–C1377.