Guanosine 5'-O- (2-thiodiphosphate) (trisodium)
Guanosine 5'-O- (2-thiodiphosphate) (trisodium) (GDPβS (trisodium) ) is a non-hydrolyzable derivative of GDP. Guanosine 5'-O- (2-thiodiphosphate) (trisodium) is an inhibitor of adenylyl caclase (AC) (Ki = 600 nM) . Guanosine 5'-O- (2-thiodiphosphate) (trisodium) partially activates AC in the absence of GPT in cerebral cortex membranes of rodent models (EC50 = 400 nM) . Guanosine 5'-O- (2-thiodiphosphate) (trisodium) prevents the release of norepinephrine-induced nitric oxide in cardiac ventricular myocytes[1][2][3].
Product Specifications
Product Name Alternative
GDPβS (trisodium)
UNSPSC
12352005
Target
Adenylate Cyclase
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Concentration
10 mM * 437.92 μL in Water
Purity
97.1
Smiles
NC1=NC(C2=C(N1)N(C=N2)[C@@H]3O[C@H](COP(OP(O[Na])(S[Na])=O)(O[Na])=O)[C@@H](O)[C@H]3O)=O
Molecular Formula
C10H12N5Na3O10P2S
Molecular Weight
525.21
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF594 conjugate, 0.1mg/mL
Von Willebrand Factor (3E2D10), CF740 conjugate, 0.1mg/mL
