GTPγS (tetralithium)

GTPγS (Guanosine 5'-[γ-thio]triphosphate) tetralithium is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS tetralithium to couple with G- protein α, to study its effect on kinase activity. GTPγS tetralithium acts as a component of lysis buffer[1][2][3][4].

Product Specifications

CAS Number

[94825-44-2]

Product Name Alternative

Guanosine 5'-[γ-thio]triphosphate (tetralithium)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

GLUT

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Purity

96.04

Solubility

H2O : ≥ 100 mg/mL

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O[C@@H]1COP(OP(OP(S[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O

Molecular Formula

C10H12Li4N5O13P3S

Molecular Weight

562.98

Precautions

H315, H319, H335

References & Citations

[1]Julie G Hensler, et al. Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration. Neuropsychopharmacology. 2002 May;26 (5) :565-73.|[2]Pilar Sánchez-Blázquez, et al. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal. 2009 Sep;21 (9) :1444-54.|[3]Xufeng Wu, et al. Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell. 2002 May;13 (5) :1735-49.|[4]Li-Bin Liu, et al. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J Biol Chem. 2003 Aug 8;278 (32) :30157-69. doi: 10.1074/jbc.M301511200.